Organs-on-chips are newest human biology experimental tool, which can mimic from thumping hearts to breathing lungs. These devices closely resemblance the components of the computer than human body parts, but the scientists have now formed a functional archetypal for an entire array of organs like liver, lung, and also the reproductive system of female.
Scientists are optimistic that these devices can help in modeling disease and simplify drug development process.
Among the 15 different human organs on chips developed at the Wyss Institute, the first was the lung-on-a-chip. It is an indistinct, thumb size device which comprises of two networks: an air-filled upper canal with human alveolar epithelial lining, and a lower canal which is has the blood vessels with WBC containing solutions lining. These scientists have combined organ chips with the mechanical forces—for instance, peristaltic movement of the gut chip and pulsations of blood vessels in the kidney chip.
Ingber, the scientist from Wyss Institute stated that “This one lung alveolus chip provided proof-of-principle for modeling normal organ-level physiology and disease, discovering new insights into the importance of physical forces, finding new therapeutic targets and even a new drug.”
The latest creations of the institute are the airway-on-a-chip. This is alike to the initial lung chip, but in place of alveolar cells, the device has the lining of the human bronchial epithelial cells. This device is already used as the chip to model COPD (chronic obstructive pulmonary disease) and asthmatic conditions. The device is also used for studying the smoking effects on the bronchial epithelium by attaching it up to an appliance that mimics the exhalation and inhalation process of the a person during smoking process.
– Rikitha K Murthy,